A microarray data analysis framework for postmortem tissues.

Edmund S Jackson; Matt T Wayland; William Fitzgerald; Sabine Bahn

doi:10.1016/j.ymeth.2005.09.006

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A microarray data analysis framework for postmortem tissues.

Edmund S Jackson·Matt T Wayland·William Fitzgerald·Sabine Bahn

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Abstract

This paper will give a complete methodological approach to the processing of oligonucleotide microarray data from postmortem tissue, particularly brain matter. Attention will be drawn to each of the important stages in the process; specifically the quality control, gene expression value calculation, multiple hypothesis testing and correlation analyses. We shall initially discuss the theoretical foundations of each individual method and subsequently apply the ensemble to a sample data set to illustrate and visualise important points.

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Algorithms Autopsy Computational Biology Diagnosis Gene Expression Profiling Models, Biological Oligonucleotide Array Sequence Analysis Quality Control Journal Article Research Support, Non-U.S. Gov't

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Edmund S Jackson, Matt T Wayland, William Fitzgerald, Sabine Bahn. 2005. A microarray data analysis framework for postmortem tissues.. https://doi.org/10.1016/j.ymeth.2005.09.006

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