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PubMed · 16213194

Structure-function studies of DNA polymerase lambda.

Miguel Garcia-Diaz·Katarzyna Bebenek·Guanghua Gao·Lars C Pedersen·Robert E London·Thomas A Kunkel
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Abstract

DNA polymerase lambda is a member of the X family of polymerases that is implicated in non-homologous end-joining of double-strand breaks in DNA and in base excision repair of DNA damage. To better understand the roles of DNA polymerase lambda in these repair pathways, here we review its structure and biochemical properties, with emphasis on its gap-filling polymerization activity, its dRP lyase activity and its unusual DNA synthetic (in)fidelity.

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DNA Polymerase betaHumansNucleic Acid ConformationPhosphorus-Oxygen LyasesProtein Structure, TertiaryStructure-Activity RelationshipJournal ArticleResearch Support, N.I.H., IntramuralReview

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Miguel Garcia-Diaz, Katarzyna Bebenek, Guanghua Gao, Lars C Pedersen, Robert E London, Thomas A Kunkel. 2005-10-04. Structure-function studies of DNA polymerase lambda.. https://doi.org/10.1016/j.dnarep.2005.09.001

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