[Bioabsorbable osteofixation devices].

D Iera; A J Haddad; G K B Sándor; N Ashmmakhi

doi:10.1016/j.anplas.2005.04.006

Home/Archive/PubMed

PubMed · 16181721

[Bioabsorbable osteofixation devices].

D Iera·A J Haddad·G K B Sándor·N Ashmmakhi

View original source ↗Export metadata ↓

Abstract

There is continued interest in the development of new biomaterials. The application of new implantable biomaterials requires intense research and thorough evaluation. Much time and effort has been required to overcome the risks and problems associated with the bioabsorbable devices. For surgical bone fixation, these materials were investigated since the 1960's. Different polymer properties were explored to ensure adequate strength and biocompatibility. High-molecular-weight bioabsorbable polymers were initially used, followed by addition of reinforcement materials. The most recent materials are self-reinforced, small yet strong devices. The newer generations contain bioactive substances such as antibiotics and growth factors. Bioabsorbable materials are constantly changing as we try to adopt the principles of tissue engineering. Surgeons are using new techniques to exploit these polymers and their bioabsorbable properties. It is hoped that this multidisciplinary approach of surgery and research will continue to help the further evolution of biomaterial science.

Explore related subjects

Absorbable Implants Humans Internal Fixators Orthopedic Procedures Polyesters Polyglycolic Acid Journal Article Review

Keep this discovery

Explore connections, maps & timelines

BibTeX RIS

D Iera, A J Haddad, G K B Sándor, N Ashmmakhi. 2005-09-21. [Bioabsorbable osteofixation devices].. https://doi.org/10.1016/j.anplas.2005.04.006

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

PubMed2007

A novel poly(ethylene glycol)-fibrinogen hydrogel for tibial segmental defect repair in a rat model.

The aim of this study is to investigate regeneration in a segmental bone defect using a novel fibrinogen-based hydrogel material. The use of hydrogels made from poly(ethylene glycol) (PEG) conjugated to fibrinogen for this purpose may be better to conventional fibrin-based materials as it offers an additional degree of control over the structural characteristics and biodegradation of the material. At the same time, it maintains some of the inherent biofunctionality of the fibrinogen molecule. PEGylated fibrinogen hydrogels with various degrees of proteolytic resistance based on PEG and fibrinogen composition were designed for slow, intermediate, and fast biodegradation. The hydrogels were implanted into 7-mm segmental rat tibial defects without additional osteoinductive factors with the rationale that the ingrowth matrix will displace the normal fibrin clot while sustaining a similar healing effect for a longer duration. Histological and X-ray results confirmed that the extent and distribution of newly formed bone in the defect after 5 weeks strongly parallels the biodegradation pattern of the implanted material. When compared to nonunions in animals treated with the fast-degrading implants and untreated control animals, the rats implanted with the intermediate-degrading material exhibited osteoneogenesis. This data supports the hypothesis that the perseverance of the PEGylated fibrinogen material can be synchronized with the optimal healing characteristics of a segmental osseous defect and that the consequent sustained release of fibrinogen fragments facilitates the osteogenic response at the injury site. The PEGylated fibrinogen material may, therefore, be a highly efficacious material for promoting the healing of bone defects and especially nonunion fractures.

Absorbable Implants↗

PubMed2007

Pores in synthetic nerve conduits are beneficial to regeneration.

Current opinion holds that pores in synthetic nerve guides facilitate nerve regeneration. Solid factual support for this opinion, however, is absent; most of the relevant studies assessed only morphological parameters and results have been contradictory. To evaluate the effect of pores, the rat sciatic nerve was either autografted or grafted with nonporous, macroporous (10-230 mum), and microporous (1-10 microm) biodegradable epsilon-caprolactone grafts. Twelve weeks later, the grafted nerves were resected, and the electrophysiological properties were determined in vitro. Subsequently midgraft-level sections were inspected, and peroneal nerve sections were evaluated morphometrically. Finally, the gastrocnemic and tibial muscle morphometrical properties were quantified. The microporous nerve graft performed much better than the nonporous and macroporous grafts with respect to most parameters: it was bridged by a free floating bundle that contained myelinated nerve fibers, there were more nerve fibers present distal to the graft, the electrophysiological response rate was higher, and the decrease in muscle cross-sectional area was markedly smaller. Hence, the present study demonstrates the beneficial effect of synthetic nerve guide pores on nerve regeneration, although with the caveat that not pores per se, but only small (1-10 microm) pores were effective.

Absorbable Implants↗

PubMed2007

First-in-human implantation of a fully bioabsorbable drug-eluting stent: the BVS poly-L-lactic acid everolimus-eluting coronary stent.

The first-in-human fully bioabsorbable drug-eluting stent (BVS poly-L-lactic acid everolimus-eluting coronary stent) implantation was performed at Auckland City Hospital, New Zealand as part of the ABSORB trial. There were no adverse events in-hospital or by 1 month. A stent that supports the vessel when needed, delivers an antiproliferative drug then disappears has theoretical advantages with regard to CT and MRI compatibility, restored vessel vasomotion, and facilitated future percutaneous intervention or surgical grafting to the treated site.

Absorbable Implants↗