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PubMed · 16053242

Dietary approach to decrease aging-related CNS inflammation.

M H Noyan-Ashraf·Z Sadeghinejad·B H J Juurlink
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Abstract

We demonstrate that the spontaneously hypertensive rat stroke-prone rat (SHRsp) undergoes premature aging of the CNS compared to the related normotensive Wistar Kyoto rat (WKY) as demonstrated by presence of activated microglia/macrophages, increased expression of inducible nitric oxide synthase and increased astrogliosis. We tested the hypothesis that dietary intake of phase 2 protein inducers would decrease these aging-associated degenerative changes. The source of dietary phase 2 protein inducers was dried broccoli sprouts of a cultivar containing high amounts of glucoraphanin that gives rise to phase 2 protein-inducing isothiocyanate sulforaphane. This diet significantly decreased the aging-related degenerative changes in the SHRsp CNS. We conclude that modest changes in diet may have profound effects on the aging CNS.

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AgingAnimalsAstrocytesBiomarkersBlotting, WesternBrainBrain ChemistryBrassicaCentral Nervous System DiseasesDietGlucoseGlucosinolatesImidoestersImmunohistochemistryInflammationMacrophagesMicrogliaNitric Oxide SynthaseNitric Oxide Synthase Type IIOximesProtein BiosynthesisRatsRats, Inbred SHRRats, Inbred WKYSpinal CordSulfoxidesJournal ArticleResearch Support, Non-U.S. Gov't

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M H Noyan-Ashraf, Z Sadeghinejad, B H J Juurlink. 2005. Dietary approach to decrease aging-related CNS inflammation.. https://doi.org/10.1080/10284150500069470

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