Search PubMed⌕ Search
Home/Archive/PubMed

PubMed · 16007325

[Upper cervical chondrosarcoma].

C J Domínguez·S Martín-Ferrer·J Rimbau·C Joly
View original source ↗Export metadata ↓

Abstract

Spinal chondrosarcoma are extremely rare and slowly growing tumors. They have been reported in thoraco-lumbar spine and lower cervical spine. Our case, a female, has a tumor located in the axis with extension into C3 and then caudally to C4 as the disease progressed. We present a technical innovation in spinal stabilization and compare our result with previously reported cases.

Explore related subjects

Antineoplastic Combined Chemotherapy ProtocolsAxis, Cervical VertebraBrachytherapyCervical VertebraeChondrosarcomaDisease ProgressionDoxorubicinFemaleHumansIfosfamideInternal FixatorsLymphatic MetastasisMiddle AgedNeoplasm Recurrence, LocalSpinal NeoplasmsTomography, X-Ray ComputedTreatment FailureCase ReportsEnglish AbstractJournal Article

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

C J Domínguez, S Martín-Ferrer, J Rimbau, C Joly. 2005. [Upper cervical chondrosarcoma].. https://pubmed.ncbi.nlm.nih.gov/16007325/

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

PubMed2007

Therapy-related acute myeloid leukemia in a child with Noonan syndrome and clonal duplication of the germline PTPN11 mutation.

A 4-year-old girl with Noonan syndrome (NS) and constitutive PTPN11 mutation presented with stage 4 neuroblastoma and was treated by intensive chemotherapy. During the treatment, cytogenetic analysis revealed the development of a hyperdiploid clone with duplication of the germline PTPN11 mutation in a morphologically normal bone marrow. A few months later, the patient developed acute myelomonoblastic leukemia with an additional clonal deletion of 7q. Although, we cannot conclude whether there is an association between NS and neuroblastoma, this case suggests that duplication of germline PTPN11 mutations, potentially induced by chemotherapy, contributes to leukemogenesis in patients with NS.

Antineoplastic Combined Chemotherapy Protocols↗
PubMed2007

Endodermal sinus tumor of the vagina.

Malignant germ cell tumors of the vagina represent a critical site for local treatment. We report on our experience with two vaginal endodermal sinus tumors. Treatment with PEB regimen induced both tumor regression and alpha fetoprotein normalization. One patient had a residual lesion that was biopsied twice and no viable tumor cells were ever found. Both patients remained alive and disease-free, without having had surgical procedures except for biopsies. Platinum-based chemotherapy is able to achieve complete remissions and should be considered for vaginal endodermal sinus tumors.

Antineoplastic Combined Chemotherapy Protocols↗
PubMed2007

Acute myeloid leukemia in a child with hereditary thrombocytopenia.

A child with a known diagnosis of an autosomal dominant macrothrombocytopenia, Fechtner Syndrome, developed acute myeloid leukemia (AML). Recently the disease gene for the inherited macrothrombocytopenias has been identified as MYH9, encoding for non-muscle myosin heavy chain-A. MYH9 has never been associated with the development of acute leukemia, but MYH11 is disrupted in the M4 eosinophilia sub-type of AML (inv16). The patients leukemic blasts did carry the common t(8;21) which yields an AML1-ETO fusion protein that inhibits AML-1. Despite his thrombocytopenia, the patient successfully completed intensive bone marrow cytoreduction without significant bleeding complications and is now in remission for over 3 years.

Antineoplastic Combined Chemotherapy Protocols↗