Mapping postnatal mouse brain development with diffusion tensor microimaging.

Jiangyang Zhang; Michael I Miller; Celine Plachez; Linda J Richards; Paul Yarowsky; Peter van Zijl; Susumu Mori

doi:10.1016/j.neuroimage.2005.03.009

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Mapping postnatal mouse brain development with diffusion tensor microimaging.

Jiangyang Zhang·Michael I Miller·Celine Plachez·Linda J Richards·Paul Yarowsky·Peter van Zijl·Susumu Mori

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Abstract

While mouse brain development has been extensively studied using histology, quantitative characterization of morphological changes is still a challenging task. This paper presents how developing brain structures can be quantitatively characterized with magnetic resonance diffusion tensor microimaging coupled with techniques of computational anatomy. High resolution diffusion tensor images of ex vivo postnatal mouse brains provide excellent contrasts to reveal the evolutions of mouse forebrain structures. Using anatomical landmarks defined on diffusion tensor images, tissue level growth patterns of mouse brains were quantified. The results demonstrate the use of these techniques to three-dimensionally and quantitatively characterize brain growth.

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Algorithms Animals Animals, Newborn Brain Brain Mapping Corpus Callosum Diffusion Magnetic Resonance Imaging Hippocampus Image Interpretation, Computer-Assisted Male Mice Mice, Inbred C57BL Neocortex Journal Article Research Support, N.I.H., Extramural Research Support, U.S. Gov't, P.H.S.

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Jiangyang Zhang, Michael I Miller, Celine Plachez, Linda J Richards, Paul Yarowsky, Peter van Zijl, Susumu Mori. 2005-04-21. Mapping postnatal mouse brain development with diffusion tensor microimaging.. https://doi.org/10.1016/j.neuroimage.2005.03.009

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