PubMed · 15959952
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Robert H Dworkin, Peter Kirkpatrick. 2005. Pregabalin.. https://doi.org/10.1038/nrd1756
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BACKGROUND: A newly developed questionnaire to measure the satisfaction of chronic pain patients with their analgetic treatment is introduced. METHODS: Based on pilot studies, a multidimensional questionnaire (QAMPAS) for the measurement of patient satisfaction was developed. In addition to a module on general patient satisfaction, it includes two specific modules with regard to medical treatment using tablets and transdermal systems (patches). In a validation study the questionnaire was administered at two measurement points to ambulatory chronic pain patients. RESULTS: The QAMPAS subscales possess satisfactory psychometric properties. Medication-specific satisfaction shows a well-differentiated multidimensional structure. With minor limitations, correlations with the general patient satisfaction module and the SF-36 and BPI subscales indicate it to be a valid instrument. CONCLUSION: The QAMPAS questionnaire is a standardized instrument with satisfactory psychometric properties for the measurement of patient satisfaction with their analgesic treatment.
BACKGROUND: The present research was performed to investigate the influence of preoperative information on pain given by the nursing staff on postoperative pain perception in patients. METHODS: A randomized controlled interventional study was conducted in 93 patients undergoing cardiac surgery at the University Hospital Erlangen. One day before the surgery all participants were evaluated using the Eysenck Personality Questionnaire, patients of the treatment group were additionally trained by a member of the nursing staff in pain behaviour. After discharge from the intensive care unit the pain experience of the patients was evaluated using standardized questionnaires. RESULTS: Of the 93 patients, 73 finished the study protocol and were analyzed. The pain experience was not significantly different between the two study groups. Patients with increased levels of neuroticism (characterized by emotional lability) regardless of study group more frequently reported pain values above 3/10. CONCLUSION: No significant modulation of postoperative pain experience was achieved by preoperative information on pain. However, it cannot be ruled out that this intervention, particularly in view of the reduction in anxiety, may form a significant element of perioperative pain management.
MD-354 (m-chlorophenylguanidine) is a 5-HT3/alpha2B-adrenoceptor ligand. Both receptors play a role in antinociception. In the mouse tail-flick assay, subcutaneously administered MD-354 was inactive as an analgesic. However, a combination of an inactive dose of clonidine (0.25 mg/kg) with an inactive dose of MD-354 (6 mg/kg) produced a substantial antinociceptive effect (maximal possible effect=66%). Considering the 5-HT3 receptor partial agonist properties of MD-354, the analgesia enhancing effect of MD-354 on clonidine might be associated, at least in part, with its 5-HT3 receptor agonist or antagonist activity. Combinations of an inactive dose of clonidine (0.25 mg/kg) with 5-HT3 receptor antagonists (tropisetron, zacopride and ondansetron) were examined. Saline-like doses of tropisetron, zacopride and ondansetron significantly enhanced the antinociceptive effect of clonidine (combinations: maximal possible effect=86%, 82% and 79% respectively), suggesting that MD-354 may enhance the analgesic actions of clonidine, at least in part, through a 5-HT3 receptor antagonist mechanism.