PubMed · 1589455
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H G Schweim, A Calvör, P Kammeyer. 1992. [Molstar--modeling software for teaching].. https://doi.org/10.1002/pauz.19920210208
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Within the broad field called "supramolecular chemistry," there is a sector that is based on the use of metal atoms or ions as key elements in promoting the assembly and dictating the main structural features of the supramolecular products. Considerable success has been achieved by using MM bonded dimetal entities in this role. Metal-metal bonded cationic complexes of the [M(2)(DAniF)(n)(MeCN)(8-2n)]((4-n)+) type, where M = Mo or Rh and DAniF is an N,N'-di-p-anisylformamidinate anion, have been used as subunit precursors and then linked by various equatorial and axial bridging groups such as polycarboxylate anions, polypyridyls, and polynitriles. Characterization of the products by single-crystal x-ray diffraction, cyclic voltammetry, differential pulse voltammetry, NMR, and other spectroscopic techniques has revealed the presence of discrete tetranuclear (pairs or loops), hexanuclear (triangles), octanuclear (squares), and dodecanuclear (cages) species and one-, two-, or three-dimensional molecular nanotubes. These compounds display a rich electrochemical behavior that is affected by the nature of the linkers.
Small, cell-permeable and target-specific chemical ligands offer great therapeutic value. They can also be used to dissect diverse biological processes, such as cellular metabolism, signal transduction and intracellular protein trafficking. With cutting-edge technologies in synthetic chemistry and ligand screening and identification, chemical ligands have become more readily available for research. Chemical ligands are used increasingly in genomics approaches to understand the global functions of proteins, an emerging frontier called 'chemical genomics'. Chemical genomics should greatly accelerate discovery in biology and medicine in the near future.