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PubMed · 15862590

Background selection and population differentiation.

Xin-Sheng Hu·Fangliang He
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Abstract

A general analytical formula is derived, which predicts the effects of background selection on population differentiation at a neutral locus as a result of its linkage with selected loci of deleterious mutations. The theory is based on the assumptions of random mating, multiplicative fitness, and weak selection in hermaphrodite plants in the island model of population structure. The analytical results show that Fst at the neutral locus increases as a result of the effects of background selection, regardless of the dependence or independence among linked background selective loci. The increment in Fst is closely related to the magnitude of linkage disequilibria between the neutral locus and selected loci, and can be estimated by the ratio of Fst with background selection to Fst without background selection minus one. The steady-state linkage disequilibrium between a neutral locus and a selected locus in subpopulations, primarily attained by gene flow, decreases with the recombination rate, and can be enhanced when there are dependence among linked selected loci. Monte Carlo computer simulations with two- and three-locus models show that the analytical formulae perform well under general conditions. Application of the present theory may aid in analyzing the genome-wide mapping of the effect of background selection in terms of Fst.

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Computer SimulationDisorders of Sex DevelopmentGene FrequencyGenes, PlantGenetic LinkageLinkage DisequilibriumModels, GeneticMonte Carlo MethodPlantsSelection, GeneticJournal ArticleResearch Support, Non-U.S. Gov't

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Xin-Sheng Hu, Fangliang He. 2005-07-21. Background selection and population differentiation.. https://doi.org/10.1016/j.jtbi.2005.01.004

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