Infection with HIV-1 induces a decrease in mtDNA.

Miriam Casula; Irene Bosboom-Dobbelaer; Karlijn Smolders; Sigrid Otto; Margreet Bakker; Michel P de Baar; Peter Reiss; Anthony de Ronde

doi:10.1086/429412

PubMed · 15809905

Infection with HIV-1 induces a decrease in mtDNA.

Miriam Casula·Irene Bosboom-Dobbelaer·Karlijn Smolders·Sigrid Otto·Margreet Bakker·Michel P de Baar·Peter Reiss·Anthony de Ronde

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Abstract

Cross-sectional studies have suggested that infection with human immunodeficiency virus (HIV) type 1 could reduce the mitochondrial DNA (mtDNA) content of blood cells. We investigated mtDNA content in peripheral blood mononuclear cells (PBMCs) obtained from 36 antiretroviral therapy-naive documented HIV-1 seroconverters, before and after seroconversion. mtDNA content statistically significantly decreased 1 year after seroconversion and showed a nonsignificant decrease during the subsequent 4 years. These findings confirm that infection with HIV-1 may, itself, reduce mtDNA content, at least within PBMCs. This could have implications for the subsequent development of mitochondrial toxicities associated with the use of nucleoside analogue reverse-transcriptase inhibitors.

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Acquired Immunodeficiency Syndrome CD4 Lymphocyte Count DNA, Mitochondrial HIV Seropositivity HIV-1 Humans Leukocytes, Mononuclear Longitudinal Studies Male Journal Article

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Miriam Casula, Irene Bosboom-Dobbelaer, Karlijn Smolders, Sigrid Otto, Margreet Bakker, Michel P de Baar, Peter Reiss, Anthony de Ronde. 2005-03-25. Infection with HIV-1 induces a decrease in mtDNA.. https://doi.org/10.1086/429412

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