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PubMed · 15802246

Dam methylation: coordinating cellular processes.

Anders Løbner-Olesen·Ole Skovgaard·Martin G Marinus
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Abstract

GATC sequences in Escherichia coli DNA are methylated at the adenine residue by DNA adenine methyltransferase (DamMT). These methylated residues and/or the level of DamMT can influence cellular functions such as gene transcription, DNA mismatch repair, initiation of chromosome replication and nucleoid structure. In certain bacteria, unlike E. coli, DamMT is essential for viability perhaps owing to its role in chromosome replication. DamMT has also been implicated as a virulence factor in bacterial pathogenesis. The origin and phylogeny of DamMT, based on sequenced genomes, has been deduced.

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Bacterial Physiological PhenomenaDNA MethylationDNA, BacterialEscherichia coli ProteinsGene Expression Regulation, BacterialSite-Specific DNA-Methyltransferase (Adenine-Specific)Journal ArticleResearch Support, N.I.H., ExtramuralResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.Review

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Anders Løbner-Olesen, Ole Skovgaard, Martin G Marinus. 2005. Dam methylation: coordinating cellular processes.. https://doi.org/10.1016/j.mib.2005.02.009

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