New anesthesia techniques.

Abstract

Advances in anesthesia involve refinements in understanding, technique, and technology. These refinements have led to better control of the anesthetic state, effective anesthesia for a wider variety of situations, and the ability to bring sicker patients to the operating room. Although the molecular mechanisms underlying the general anesthetic state are unknown, evidence suggests a specific, receptor-based effect. This concept has allowed anesthesiologists to treat anesthetic end points of immobility, lack of awareness, and autonomic control separately. It is likely that anesthesia and naturally occurring sleep interact physiologically. New, processed EEG monitors may allow anesthesiologists to titrate more finely anesthetic dose, with possible benefits in terms of speed of recovery and detection of intraoperative awareness. Since the 1990s, new anesthetic drugs (propofol, desflurane/sevoflurane, cisatracurium) have enhanced greatly control of the anesthetic state. The new intravenous anesthetic agent dexmedetomidine offers sedation with preserved respiration and cognitive function. Although its role has yet to be defined fully, it currently plays a role in ICU sedation and monitored anesthesia care. New anesthesia ventilators have better monitoring and better flow delivery at high airway pressures. These improvements significantly narrow the performance gap between anesthesia and ICU ventilators. In patients with COPD, pulmonary hypertension, or severe hypoxemia, heliox may improve gas flow, and NO may reduce pulmonary vascular resistance and improve oxygenation.