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PubMed · 15630132

Do developing B cells need antigen?

Jean-Claude Weill·Claude-Agnès Reynaud
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Abstract

Just as potentially useful T cells are positively selected by MHC-peptide complexes in the thymus, it has been proposed that self or commensal bacterial epitopes might select B cell populations with the capacity to recognize polysaccharide or protein structures on pathogens. Recent studies indicate that the repertoire of B cells entering the periphery is not shaped by specific stimuli, but that mature B cell subsets may be under different selective pressures.

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Antibody DiversityB-LymphocytesEpitopes, B-LymphocyteHumansImmunityImmunoglobulin FragmentsLymphoid TissueModels, BiologicalMutationReceptors, Antigen, B-CellSelection, GeneticSignal TransductionJournal Article

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Jean-Claude Weill, Claude-Agnès Reynaud. 2005-01-03. Do developing B cells need antigen?. https://doi.org/10.1084/jem.20042111

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