PubMed · 15603452
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Heike Fiegler, Nigel P Carter. 2004. Genomic array technology.. https://doi.org/10.1016/s0091-679x(04)75033-5
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Nucleotide variations in the human genome, such as single-nucleotide polymorphisms, have been researched more intensively since it became apparent that these deviations are linked to various diseases and also several side effects of drugs. The investigation of genomic DNA in the laboratory requires routine methods that are time-, labour-, and cost-effective. These criteria are fulfilled by so-called closed-tube methods, which are applied directly to isolated genomic DNA without any preamplification.