PubMed · 15506692
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Donato Agnusdei. 2004. Bone quality.. https://pubmed.ncbi.nlm.nih.gov/15506692/
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OBJECTIVES: Up-to-date store-wide studies regarding low back pain (LBP) among supermarket/hypermarket workers are lacking. We investigated 12-month store-wide prevalence of different categories of LBP and possible associated biomechanical, individual/psychosocial risk factors across a large supermarket/hypermarket chain. METHODS: We performed a cross-sectional study of 3,702 subjects working in a group of small/medium-sized supermarkets (n=100) and large hypermarkets (n=7) belonging to a single chain in central-northern Italy applying established ergonomics/job-satisfaction policies. Data regarding the various departments were collected by a medical check-list, physical examination and questionnaire-all conducted by qualified physicians--and were analyzed in relation to a comprehensive biomechanical risk analysis. RESULTS: The overall 12-month prevalence of LBP in our sample (with a 82% response rate) was 34.5% (36.6% for females and 30.7% for males), with few differences being found between supermarkets and hypermarkets. Different types of LBP showed significant associations with stress-related psychosomatic symptoms, but not with job satisfaction (which was high). CONCLUSIONS: These encouraging data provide relevant information regarding workers operating in supermarkets/hypermarkets with an active commitment to ergonomic and job-satisfaction policies.
The relative effectiveness of different anions in crystallizing proteins follows a reversed Hofmeister sequence for pH pI. The phenomenon has been known almost since Hofmeister's original work but it has not been understood. It is here given a theoretical explanation. Classical electrolyte and double layer theory deals only with electrostatic forces acting between ions and proteins. Hydration and hydration interactions are dealt with usually only in terms of assumed hard core models. But there are, at and above biological salt concentrations, other non-electrostatic (NES) ion-specific forces acting that are ignored in such modeling. Such electrodynamic fluctuation forces are also responsible for ion-specific hydration. These missing forces are variously comprehended under familiar but generally unquantified terms, typically, hydration, hydrogen bonding, pi-electron-cation interactions, dipole-dipole, dipole-induced dipole and induced dipole-induced dipole forces and so on. The many important body electrodynamic fluctuation force contributions are accessible from extensions of Lifshitz theory from which, with relevant dielectric susceptibility data on solutions as a function of frequency, the forces can be extracted quantitatively, at least in principle. The classical theories of colloid science that miss such contributions do not account for a whole variety of ion-specific phenomena. Numerical results that include these non-electrostatic forces are given here for model calculations of the force between two model charge-regulated hen-egg-white protein surfaces. The surfaces are chosen to carry the same charge groups and charge density as the protein. What emerges is that for pH pI (where anions are co-ions) the forces increase in the order NaCl<NaI<NaSCN. This is in excellent agreement with both solubility experiments and experiments using SAXS. The results are also consistent with cation effects observed in protein solutions. Our results may provide some insights into a long-standing problem in solution chemistry and biology.
Needle-free jet injections constitute an important method of drug delivery, especially for insulin and vaccines. This report addresses the mechanisms of interactions of liquid jets with skin. Liquid jets first puncture the skin to form a hole through which the fluid is deposited into skin. Experimental studies showed that the depth of the hole significantly affects drug delivery by jet injections. At a constant jet exit velocity and nozzle diameter, the hole depth increased with increasing jet volume up to an asymptotic value and decreased with increasing values of skin's uniaxial Young's modulus. A theoretical model was developed to predict the hole depth as a function of jet and skin properties. A simplified model was first verified with polyacrylamide gels, a soft material in which the fluid mechanics during hole formation is well understood. Prediction of the hole depth in the skin is a first step in quantitatively predicting drug delivery by jet injection.