Drapc1 expression during mouse embryonic development.

Tomi Jukkola; Natalia Sinjushina; Juha Partanen

doi:10.1016/j.modgep.2004.03.006

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Drapc1 expression during mouse embryonic development.

Tomi Jukkola·Natalia Sinjushina·Juha Partanen

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Abstract

We identified the mouse homolog of human DRAPC1 (APCDD1) gene, shown to be a target of Wnt/beta-catenin signaling pathway in cancer cell lines. Analysis of its spatiotemporal expression in mouse embryos from E7.5 to E14 showed that Drapc1 is expressed during development of the extraembryonic structures, nervous system, vascular system and inner ear. In addition, Drapc1 is expressed in the mesenchyme of several developing organs at sites of epithelio-mesenchymal interactions. Drapc1 expression was also found in the hair follicles of the adult mouse skin. Similarity of Drapc1 expression pattern to location of active beta-catenin in developing mouse embryo further suggests that mouse Drapc1 is a novel in vivo target gene of Wnt/beta-catenin signaling pathway.

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Adenomatous Polyposis Coli Protein Amino Acid Sequence Animals Brain Female Gene Expression Regulation, Developmental Hippocampus Humans In Situ Hybridization Intracellular Signaling Peptides and Proteins Membrane Proteins Mice Molecular Sequence Data Phylogeny Sequence Homology, Amino Acid Time Factors Tissue Distribution Journal Article Research Support, Non-U.S. Gov't

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Tomi Jukkola, Natalia Sinjushina, Juha Partanen. 2004. Drapc1 expression during mouse embryonic development.. https://doi.org/10.1016/j.modgep.2004.03.006

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