PubMed · 15438546
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E SCHUTZE. 1950-06-02. [Cortical osteoid].. https://pubmed.ncbi.nlm.nih.gov/15438546/
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The demand for organ transplantations greatly exceeds the number of organ donors (OD) and it is likely that this discrepancy will continue. There is a continuously growing demand for biostatic allogenic bone transplantation mostly for orthopedic reconstructions. The bone material is predominantly harvested during postmortem examinations in forensic medicine departments. The collected amounts are not enough so the material need to be acquired from other sources. Bone collecting from OD seems to be the optimal solution. Between January 2000 and December 2005, 1,883 out of 2,601 organ donors fulfilled the criteria for bone donation, but only 42 bone harvesting (BH) were performed being only 2.22% of all suitable cases. The main reasons for so few bone procurements were: lack of acceptance of bone procurement by relevant part of donors' families, insufficient cooperation between tissue banks and transplantation teams, lack of equipment for BH, and no experience in bone procurement.
BACKGROUND: The number of in vivo clinical biomedical experiments based on computed tomography is increasing. International radiation-protection bodies are promoting the use of low-dose computed tomography to reduce radiation absorption by the subject undergoing imaging. On the other hand no data exist in the literature to quantify whether or not low-dose computed tomography would lead to a decrease of result quality when used for three-dimensional bone modeling and related measurements. METHODS: This paper aimed at finding a consensus between minimal X-ray radiation of the subject, and satisfactory image data quality, especially for accurate three-dimensional bone modeling. Several standard computed tomography and low-dose computed tomography sequences were analyzed in three tests and statistically compared. FINDINGS: Absence of significant difference between standard and low-dose computed sequences indicated that the low-dose setting would not produce less accurate three-dimensional models, while it decreased the effective X-ray dose up to 90% compared to standard settings. INTERPRETATION: Low-dose computed tomography seems suitable for accurate three-dimensional bone modeling, while the related effective X-ray radiation is low. Such setting is therefore advised for any in vivo medical imaging aiming to collect bone data.
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