The non-existent aging program: how does it work?

Dale E Bredesen

doi:10.1111/j.1474-9728.2004.00121.x

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The non-existent aging program: how does it work?

Dale E Bredesen

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Abstract

Summary Aging and lifespan determination have been viewed, in the most well-accepted theories, as nonprogrammatic, and are thought to result from the evolutionary selection for early fitness at the expense of late survival. Here, recent data implicating potentially programmatic aspects of aging and lifespan determination are discussed, and analogies between programmed cell death and programmed organismal death are offered. It is hoped that the recognition of at least the possibility of a programmatic aspect, or aspects, to the determination of longevity and the process of aging will help to optimize our chances to identify appropriate therapeutic targets both for longevity enhancement and disease prevention.

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Aging Animals Cell Death Drosophila melanogaster Energy Metabolism Humans Immune System Models, Biological Oxidative Stress Selection, Genetic Journal Article

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Dale E Bredesen. 2004. The non-existent aging program: how does it work?. https://doi.org/10.1111/j.1474-9728.2004.00121.x

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