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PubMed · 15377826

Microneedle insertion force reduction using vibratory actuation.

Ming Yang·Jeffrey D Zahn
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Abstract

The effect of vibratory actuation on microneedle insertion force was investigated. Hollow micro hypodermic injection needles were fabricated by a two-wafer polysilicon micromolding process. A vibratory actuator operating in the kHz range was coupled with the hypodermic microneedles. The force to insert microneedles into excized animal tissue was measured with a load cell. Results showed a greater than 70% reduction in microneedle insertion force by using vibratory actuation. The application of vibratory actuation provides a promising method to precisely control the microneedle insertion forces to overcome microneedle structural material limitations, minimize insertion pain, and enhance the efficiency of drug delivery.

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Drug Delivery SystemsEquipment DesignEquipment Failure AnalysisInjectionsMicroinjectionsMicromanipulationMiniaturizationNeedlesStress, MechanicalVibrationEvaluation StudyJournal Article

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BibTeXRIS

Ming Yang, Jeffrey D Zahn. 2004. Microneedle insertion force reduction using vibratory actuation.. https://doi.org/10.1023/b%3Abmmd.0000042046.07678.2e

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