PubMed · 15338564
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Sir John Meurig Thomas. 2004. Max Perutz.. https://pubmed.ncbi.nlm.nih.gov/15338564/
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Addressing health inequity is now recognized as a clinical competency in medical education. We examined the career and writings of Robert Wilson Jr. (1867-1946), longtime dean of the Medical College of the State of South Carolina during the Jim Crow Era, using primary and secondary sources within the context of systemic and structural racism, particularly in South Carolina. Wilson used public health data to refute the "Black Extinction Hypothesis" rooted in social Darwinism. He challenged assumptions of inherent Black susceptibility to tuberculosis, linking disease instead to social determinants of health. He also identified disproportionate mortality from kidney and cardiovascular disease among Black populations, anticipating modern health disparities research. Wilson further acknowledged systemic injustice and implicated structural conditions, including housing, in shaping outcomes. In an era of continuing health inequity and racial health disparities, Wilson applied empirical evidence to reject biological determinism, identify outcomes disparities, and advocate for racial justice.
A personal narrative of my time in the Hunt laboratory and beyond is provided. The impact of the Hunt laboratory on the analysis of peptides and proteins by tandem mass spectrometry is described in the context of the time.
In 1957 John Chamley and I began to discuss the question of cement fixation of femoral prostheses. This was an independent development, because we had no knowledge of any other work in this area. Our conclusion was to grout in the prosthesis with a suitable cement. I selected a cold-curing acrylic denture repair material called Nu-Life as most appropriate. This material proved satisfactory in laboratory and clinical trials, and in 1958 Chamley undertook hip replacement using a cemented femoral prosthesis in six patients. This clinical success aroused great interest and some skepticism, because it was not always appreciated that Charnley and I had a substantial body of scientific data that justified this new approach to arthroplasty. Not surprisingly,the clinical aspects received most emphasis in the next decade. The scientific data were published mostly in the dental literature and were forgotten by the time cementation arthroplasty was generally accepted and so were rediscovered in subsequent years.