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Longitudinal cerebral perfusion decrease in mild alzheimer's disease revealed by SPECT with statistical parametric mapping method.

Yi-Chung Lee·Ren-Shyan Liu·Yi-Chu Liao·Pei-Ning Wang·Ker-Neng Lin·Hsiu-Chih Liu
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Abstract

Fifteen patients with mild Alzheimer's disease received baseline and follow-up technetium-99m hexamethylpropylene amine oxime SPECT examinations paired with neuropsychological assessments, including the Cognitive Ability Screening Instruments (CASI). The differences between baseline and follow-up SPECT images were analyzed by the voxel-based paired t test of the statistical parametric mapping technique. A simple regression analysis was also conducted to analyze the correlation between CASI sub-scores and both sets of SPECT images. In comparison with baseline images, cerebral perfusion at follow-up was significantly reduced in the left superior and middle temporal gyri, right middle and inferior temporal gyri, and right fusiform gyrus. A significant correlation was demonstrated between the list-generating fluency CASI sub-score and perfusion of the left fusiform gyrus. The visual construction sub-score was significantly correlated with perfusion of the right superior and medial frontal gyri.

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AgedAged, 80 and overAlzheimer DiseaseAttentionBrain MappingCerebral CortexChemotherapy, Cancer, Regional PerfusionCognitionFemaleFollow-Up StudiesHumansMaleMental Status ScheduleNeuropsychological TestsRetrospective StudiesTomography, Emission-Computed, Single-PhotonClinical TrialComparative StudyJournal ArticleResearch Support, Non-U.S. Gov't

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Yi-Chung Lee, Ren-Shyan Liu, Yi-Chu Liao, Pei-Ning Wang, Ker-Neng Lin, Hsiu-Chih Liu. 2004-06-29. Longitudinal cerebral perfusion decrease in mild alzheimer's disease revealed by SPECT with statistical parametric mapping method.. https://doi.org/10.1159/000079417

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