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PubMed · 15182228

Alpha-synuclein aggregation.

Angela M Bodles·G Brent Irvine
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Abstract

Alpha-synuclein is a major component of Lewy bodies in Parkinson's disease and is found associated with several other forms of dementia. As with other neurodegenerative diseases, the ability of alpha-synuclein to aggregate and form fibrillar deposits seems central to its pathology. We have defined a sequence within the NAC region of alpha-synuclein that is necessary for aggregation. Exploitation of chemically modified analogues of this peptide may produce inhibitors of aggregation.

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Amino Acid SequenceAmyloidosisAnimalsHumansMolecular Sequence DataNerve Tissue ProteinsParkinson DiseaseProtein Structure, QuaternarySynucleinsalpha-SynucleinJournal ArticleReview

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Angela M Bodles, G Brent Irvine. 2004. Alpha-synuclein aggregation.. https://doi.org/10.2174/0929866043407084

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