Single molecule diffraction.

J C H Spence; R B Doak

doi:10.1103/physrevlett.92.198102

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Single molecule diffraction.

J C H Spence·R B Doak

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Abstract

For solving the atomic structure of organic molecules such as small proteins which are difficult to crystallize, the use of a jet of doped liquid helium droplets traversing a continuous high energy electron beam is proposed as a means of obtaining electron diffraction patterns (serial crystallography). Organic molecules (such as small proteins) within the droplet (and within a vitreous ice jacket) may be aligned by use of a polarized laser beam. Iterative methods for solving the phase problem are indicated. Comparisons with a related plan for pulsed x-ray diffraction from single proteins in a molecular beam are provided.

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Electrons Helium Membrane Proteins Powder Diffraction X-Ray Diffraction Journal Article Research Support, U.S. Gov't, Non-P.H.S.

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J C H Spence, R B Doak. 2004-05-12. Single molecule diffraction.. https://doi.org/10.1103/physrevlett.92.198102

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