Probabilistic nucleotide assembling method for sequencing by hybridization.

Takaho A Endo

doi:10.1093/bioinformatics/bth202

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Probabilistic nucleotide assembling method for sequencing by hybridization.

Takaho A Endo

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Abstract

MOTIVATION: Developing a new method of assembling small sequences based on sequencing by hybridization with many positive and negative faults. First, an interpretation of a generic traveling salesman problem is provided (i.e. finding the shortest route for visiting many cities), using genetic algorithms. Second, positive errors are excluded before assembly by a sanitization process. RESULTS: The present method outperforms those described in previous studies, in terms of both time and accuracy. AVAILABILITY: http://kamit.med.u-tokai.ac.jp/~takaho/sbh/index.html

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Algorithms Base Sequence Computer Simulation Databases, Genetic In Situ Hybridization Models, Genetic Models, Statistical Molecular Sequence Data Reproducibility of Results Sensitivity and Specificity Sequence Alignment Sequence Analysis, DNA Software Comparative Study Evaluation Study Journal Article Research Support, Non-U.S. Gov't Validation Study

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Takaho A Endo. 2004-04-08. Probabilistic nucleotide assembling method for sequencing by hybridization.. https://doi.org/10.1093/bioinformatics%2Fbth202

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