PubMed · 15016178
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M A Sperling. 2001. One step back, two steps forward.. https://doi.org/10.1034/j.1399-5448.2001.20401.x
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Precision oncology relies on integrating tumour fraction, variant allele frequency, clonal haematopoiesis of indeterminate potential assessment, pathogenicity, and clinical context into next-generation sequencing interpretation, enabling biologically informed and clinically meaningful treatment decisions while reducing the risk of overinterpreting nontumour or nonactionable genomic alterations.