PubMed · 14976279
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Donald Kennedy, Jim Austin, Kirstie Urquhart, Crispin Taylor. 2004-02-20. Supply without demand.. https://doi.org/10.1126/science.303.5661.1105
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Precision oncology relies on integrating tumour fraction, variant allele frequency, clonal haematopoiesis of indeterminate potential assessment, pathogenicity, and clinical context into next-generation sequencing interpretation, enabling biologically informed and clinically meaningful treatment decisions while reducing the risk of overinterpreting nontumour or nonactionable genomic alterations.