PubMed · 14954700
The source did not provide an abstract. Follow the original record for more information.
Explore connections, maps & timelines
R DJINDJIAN. 1952. [Oxycephaly].. https://pubmed.ncbi.nlm.nih.gov/14954700/
Cite the original work for its findings. Save a collection to share your selection of sources.
KEEP EXPLORING
We treated four patients with scaphocephaly using a combination of distraction and contraction techniques and achieved satisfactory results. Radial osteotomies in the frontal and occipital bones flattened these abnormal bossing bones and accelerated the disappearance of bony bumps created by distraction. This technique facilitates the achievement of the desired shape of the skull through fine adjustments of the distraction and contraction devices.
Explore the source record for details and available documents.
Deficient activities of multiple steroidogenic enzymes have been reported without and with Antley-Bixler syndrome (ABS), but mutations of corresponding cytochrome P450 enzymes have not been found. We identified mutations in POR, encoding P450 oxidoreductase, the obligate electron donor for these enzymes, in a woman with amenorrhea and three children with ABS, even though knock-out of POR is embryonically lethal in mice. Mutations of POR also affect drug-metabolizing P450 enzymes, explaining the association of ABS with maternal fluconazole ingestion.