MONILIASIS.

Although there are many reports on the use of expandable metallic stents for treating an airway stenosis that develops after heart lung transplantation, complications from using these stents are rarely reported. We experienced a case of Candida infection in a stent that was placed to treat a tracheal stenosis after heart lung transplantation in an 11-year-old girl. The patient had progressive shortness of breath developed from the 5th postoperative week. Chest computed tomography and bronchoscopy revealed a stenosis at the level of the anastomosis. After repeated unsuccessful trials of endoscopic ablation of the granuloma, a Palmaz metallic expandable stent (8 x 30 mm) (Johnson and Johnson Interventional Systems Co, Warren, NJ) was placed, which was followed by immediate relief of the dyspnea. Bronchoscopy conducted immediately after the stent placement showed a free floating distal stent end, which needed to be followed up. The patient had been doing well for the next 9 months after stent placement when she again had shortness of breath develop. Endoscopic examination revealed an intraluminally growing fungal mass, which was particularly severe at the distal free edge of the stent. The culture yielded Candida albicans. Aggressive antifungal agents and surgical removal of the stent were planned, but the patient died 1 day after admission.

Candidiasis↗

PubMed2004

Risk factors for pulmonary candidiasis in preterm infants with a birth weight of less than 1250 g.

UNLABELLED: To evaluate the epidemiology of pulmonary candidiasis (PC) and to identify risk factors in premature infants during the 1st month of life, all infants with a birth weight <1250 g admitted to our neonatal intensive care unit with PC between January 1994 and December 2001 were retrospectively reviewed. Infants with PC ( n =20) were compared with a control group ( n =20), matched for gestational age and birth weight, with regard to possible perinatal and postnatal risk factors. Among 325 infants with a birth weight <1250 g, 20 out of 233 ventilated infants (8.6%) developed PC. Candida albicans ( n =12) and C. parapsilosis ( n =4) were the predominant isolates. Neonates with PC were significantly different from controls with regard to male prevalence ( P =0.002), rates of preterm premature rupture of membranes (PPROM) ( P =0.02), longer duration of antibiotic therapy ( P =0.01) and of ventilation ( P =0.02). The difference between groups did not attain significance with regard to postnatal dexamethasone administration, duration of central vein catheterisation and duration of parenteral nutrition. Multivariate logistic regression analysis indicated as significant predictors of PC, among perinatal data, the male gender (OR =26.3; 95%CI 2.44 to 284) and PPROM (OR =12.3; 95%CI 1.16 to 130) and, among postnatal data, the duration of ventilation (OR =1.54; 95%CI 1.01 to 2.34). CONCLUSION: The presence of preterm premature rupture of membranes and the duration of ventilation are significant risk factors for developing pulmonary candidiasis and should be considered in the preventive efforts to reduce this disease in infants with a birth weight <1250 g.

Candidiasis↗