PubMed · 14849927
The source did not provide an abstract. Follow the original record for more information.
Explore connections, maps & timelines
T M SONNEBORN. Cellular transformations.. https://pubmed.ncbi.nlm.nih.gov/14849927/
Cite the original work for its findings. Save a collection to share your selection of sources.
KEEP EXPLORING
Germ cell development is an active process in normal testes during the first 4 years after birth, with transformation of the neonatal gonocytes into adult dark spermatogonia and then primary spermatocytes. The hormonal regulation of these changes is not fully understood, with evidence both for and against a role for gonadotrophins and androgens. Early surgical intervention in infancy aims to prevent or reverse germ cell maldevelopment. Although hormonal treatment for maldescent has been shown to be ineffective, there is still controversy over whether it may be useful as an adjunct to surgery to stimulate germ cells. Current evidence suggests that hormonal therapy may not stimulate transformation of neonatal gonocytes but may trigger prepubertal mitosis of primary spermatocytes. Further studies are required to determine the role of hormone treatment on germ cell development.
Explore the source record for details and available documents.
We describe the development of multiple malignancies in a patient with Wegener's granulomatosis treated with glucocorticosteroids, azathioprin and cyclophosphamide over 20 years. His symptoms started with a neurological disease, which is unusual. Less attention was paid to other symptoms that occurred simultaneously and were more typical manifestations of the disease. This resulted in delayed diagnosis. Despite incorrect diagnoses, he received appropriate immunosuppressive therapy. After 2 years of therapy, he developed a spinocellular carcinoma, after 12 years a basal cell carcinoma and after 19 years both a Kaposi sarcoma and a urinary bladder carcinoma. This patient illustrates a difficult therapeutic balance between prolonged treatment and the hazards of therapy. No guidelines are established to manage this clinical dilemma.