PubMed · 14735095
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Tomas B Garcia, Geoffrey T Miller. 2004. A regular or irregular irregularity?. https://pubmed.ncbi.nlm.nih.gov/14735095/
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The time to resumption of driving after insertion of an implantable cardioverter-defibrillator (ICD) was evaluated in the Dual Chamber And VVI Implantable Defibrillator trial. Most patients were advised not to drive for 3 to 6 months after the ICD was implanted. Patients were surveyed at 3-, 6-, or 9-month intervals to characterize their driving habits, with 101 of 137 (73.7%), 98 of 146 (67.1%), and 79 of 135 (58.5%) responding. Of respondents, 82% recalled being told not to drive for a specified time after ICD implantation. These patients generally obeyed recommendations (association between recommended time and time of resumption, p <0.001) from medical personnel.
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Several large well-designed clinical trials have shown that the use of diuretics is beneficial in patients with hypertension. However, similarly robust data regarding their role in chronic heart failure are lacking. Historically, diuretics were developed for treatment of sodium and water retention in oedematous disorders and clinically, they remain the most potent drugs available to relieve symptoms and eliminate oedema in the congested patient with heart failure. In the non-congested patient, however, diuretics continue to be used on a purely clinical basis without sufficient characterization of benefits, adverse effects, and potential influence on mortality. There are also concerns that chronic diuretic usage can cause adverse vascular effects, unfavourable neuroendocrine activation, electrolyte imbalances, and life-threatening arrhythmias. In this article, we review the limited evidence available regarding the benefits and perils of using diuretics in heart failure.