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PubMed · 14723943

Effects of chlorine on the decrease of estrogenic chemicals.

Byoung-Cheun Lee·Motoyuki Kamata·Yasushi Akatsuka·Makoto Takeda·Koichi Ohno·Tasuku Kamei·Yasumoto Magara
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Abstract

The effects of chlorination on the elimination of three estrogenic chemicals such as 17beta-estradiol, nonylphenol and bis-phenol A were investigated using yeast two-hybrid assay (YTA), estrogen receptor (ER) competition assay (ER-CA), and high-performance liquid chromatography/mass spectrometry (LC/MS). The results of YTA, ER-CA and the analysis of LC/MS indicated that the estrogenic activity of the above-mentioned three endocrine disruptors were significantly reduced as a result of chlorination. The decrease in estrogenic activity paralleled a decrease in estrogenic chemicals under the influence of free chlorine. One common characteristic of estrogenic chemicals is the presence of a phenolic ring. Considering that a phenolic ring is likely to undergo some sort of transformation in an aqueous chlorination solution, the above-mentioned results may be applied to the rest of the estrogenic chemicals in natural waters.

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Benzhydryl CompoundsBiological AssayChlorineChromatography, High Pressure LiquidEstradiolEstrogens, Non-SteroidalMass SpectrometryPhenolsReceptors, EstrogenWater PurificationBisphenol A CompoundsJournal Article

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Byoung-Cheun Lee, Motoyuki Kamata, Yasushi Akatsuka, Makoto Takeda, Koichi Ohno, Tasuku Kamei, Yasumoto Magara. 2004. Effects of chlorine on the decrease of estrogenic chemicals.. https://doi.org/10.1016/j.watres.2003.10.010

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