[Liver function tests in a clinical comparison].

W Stremmel; R Wojdat; R Groteguth; M Zoedler; T Ebener; C Niederau; H Becker; G Strohmeyer

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PubMed · 1471385

[Liver function tests in a clinical comparison].

W Stremmel·R Wojdat·R Groteguth·M Zoedler·T Ebener·C Niederau·H Becker·G Strohmeyer

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Abstract

Various liver function tests were evaluated in regard to a quantitative estimation of the impairment of liver function related to the Child-Pugh classification in 32 patients with cirrhosis. Only the ICG-test revealed significant differences between healthy subjects and cirrhotic patients in stadium Child A, B and C. When ICG-dye retention values were plotted as a function of the individual score units of the Child-Pugh classification, a linear relationship with a correlation coefficient of 0.7 was obtained. In contrast to the ICG-test, the MEGX- and galactose elimination capacity (GEC)-test as well as static parameters of liver function (cholinesterase activity, prealbumin concentration, coagulation factor V and VII) resulted in less significant differentiation of the various Child classes. The MEGX-test, GEC, concentration of prealbumin, coagulation factor V and VII were only weakly correlated to the score units of the Child-Pugh index. The results of this study indicate that of all evaluated parameters only the ICG-test is suitable for objective and graduated analysis of liver function in patients with cirrhosis.

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Cholinesterases Factor V Factor VII Galactose Hepatic Encephalopathy Humans Indocyanine Green Lidocaine Liver Cirrhosis Liver Function Tests Metabolic Clearance Rate Prealbumin Prothrombin Time Reference Values Serum Albumin Comparative Study Journal Article Research Support, Non-U.S. Gov't

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W Stremmel, R Wojdat, R Groteguth, M Zoedler, T Ebener, C Niederau, H Becker, G Strohmeyer. 1992. [Liver function tests in a clinical comparison].. https://pubmed.ncbi.nlm.nih.gov/1471385/

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