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PubMed · 14611937

Bleaching desensitization: background and current challenges.

David R Pepperberg
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Abstract

"Bleaching desensitization" in rod photoreceptors refers to the prolonged depression of phototransduction sensitivity exhibited by rods after their exposure to bright light, i.e., after photolysis (bleaching) of a substantial fraction of rhodopsin in the outer segments. Rod recovery from bleaching desensitization depends critically on operation of the retinoid visual cycle: in particular, on the removal of all-trans retinal bleaching product from opsin and on the delivery of 11-cis retinal to opsin's chromophore binding site. The present paper summarizes representative findings that address the mechanism of bleaching desensitization.

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Dark AdaptationHumansPhotic StimulationPhotolysisRetinal Rod Photoreceptor CellsRetinaldehydeRhodopsinVision, OcularJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.

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David R Pepperberg. 2003. Bleaching desensitization: background and current challenges.. https://doi.org/10.1016/s0042-6989(03)00484-x

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