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PubMed · 14568232

Significant association of HLA A2-DR11 with CD4 naive decrease in autistic children.

Pasquale Ferrante·Marina Saresella·Franca R Guerini·Michela Marzorati·Maria C Musetti·Adriana Guareschi Cazzullo
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Abstract

Nine autistic children and 37 ethnically homogenous controls were enrolled in the study to assess their human leukocyte antigen (HLA) pattern, and eight healthy children were studied to define their peripheral blood cell subsets. We observed a significant decrease in CD4+ naive and an increase in CD4+ memory T cells in autistic children. These differences were significantly more pronounced in the autistic children bearing the HLA A2 and DR11 alleles. These data support the hypothesis that autism could be due to an immune imbalance occurring in genetically predisposed children.

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Autistic DisorderCD4 Lymphocyte CountCD4-Positive T-LymphocytesChildFemaleFlow CytometryGene FrequencyHLA-A2 AntigenHLA-DR AntigensHLA-DR Serological SubtypesHumansMaleJournal ArticleResearch Support, Non-U.S. Gov't

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Pasquale Ferrante, Marina Saresella, Franca R Guerini, Michela Marzorati, Maria C Musetti, Adriana Guareschi Cazzullo. 2003. Significant association of HLA A2-DR11 with CD4 naive decrease in autistic children.. https://doi.org/10.1016/s0753-3322(03)00099-4

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