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PubMed · 14196783

ALCOHOLISM.

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J W NIXON, J T QUINN. 1964. ALCOHOLISM.. https://pubmed.ncbi.nlm.nih.gov/14196783/

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Suppression of symptoms of alcohol dependence and craving using high-dose baclofen.

AIMS: To further test whether the baclofen-induced suppression of motivation to consume alcohol in animals could be transposed to humans. METHODS: A patient who had neither tolerated nor benefited from other alcohol treatment modalities was put on trial with baclofen on a dosage up to 140 mg/day. RESULTS: The patient reported dramatic reduction in cravings for and preoccupation with alcohol. CONCLUSIONS: High-dose baclofen therapy was associated with complete and prolonged suppression of symptoms and consequences of alcohol-dependence.

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