PubMed · 14142272
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J DIKTANAS. 1964. [THYROID FUNCTION AND CORONARY INSUFFICIENCY].. https://pubmed.ncbi.nlm.nih.gov/14142272/
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Cardiac magnetic resonance (CMR) is a burgeoning area of noninvasive cardiac imaging. Today, its clinical utility spans from the qualitative and quantitative assessment of cardiac function and morphology to the challenging task of determining the severity and reversibility of coronary heart disease. Advances in magnet and coil design, pulse sequence, and contrast media have contributed greatly, helping CMR become the multipurpose tool of today's cardiac imaging. This article reviews and explores some of the most exciting clinical applications of CMR in the assessment of coronary artery disease.
Coronary heart disease (CHD) is a major cause of mortality in the Western world. CHD risk is known to be modified by both genetic and environmental factors. In this review, we look at the role of lipoprotein lipase (LPL) gene variants in predisposing to CHD risk and the important interaction between these genotypes and environmental factors (e.g. smoking). Gene-environmental interactions result in a greater than additive effect on risk and understanding these gene-environmental interactions has the potential not only for improving our understanding of the pathophysiology of the disease, but also in the development of new therapies and the targeting of specific therapies. For example, if a genotype increases risk in a particular environment, then those subjects would be encouraged to change their lifestyles more aggressively. Similarly at-risk subjects could be targeted with available therapies more appropriately.