PubMed · 14087867
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A POMINI. [CARAWAY].. https://pubmed.ncbi.nlm.nih.gov/14087867/
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The investigation of flower scent represents an important field of modern biological research which is directed towards special theories of biological recognition. The headspace solid phase microextraction coupled with gas chromatography-mass spectrometry was used to identify the volatile components of Carum copticum (C. copticum) cultivated in Iran. The compounds were identified according to their retention indices and mass spectra (EI, 70 eV). The effects of different parameters, such as the desorption time, the extraction temperature, the sample mass, the addition of salt, the pre-equilibration time and the extraction time, on the extraction efficiency were investigated. The optimized conditions were: the desorption time, 2 min; the extraction temperature, 58 degrees Celsius; the sample mass, 1.000 g in 4.0 mL 2.0 M NaCl solution; the pre-equilibration time, 25 min; the extraction time, 20 min. Finally, ten components were identified in the volatile components of C. copticum. The major components of C. copticum were thymol (68.2%), gamma-terpinene (13.9%), p-cymene (11.6%), myrcene (1.0%) and beta-pinene (0.6%). Precision of the proposed method is good and %RSD less than 14 was obtained.
The transfer through a membrane of the main organic components and mineral elements of Carum carvi and Foeniculum vulgare volatile oils was studied. The transfer was studied from buffer solution pH 1.1 (stomach) and pH 6.5 (intestine) to pH 7.5 (plasma) in a Sartorius model. The transferred components were measured by GC-MS for volatile components and ICP-OES for inorganic elements. The main components (trans-anethole and fenchone from F. vulgare, carvone and D-limonene from C. carvi), as well as some mineral elements (Ca, Mg, S, Zn), transferred through the membrane.
BACKGROUND: Non-ulcer dyspepsia is predominantly a self-managed condition, although it accounts for a significant number of general practitioner consultations and hospital referrals. Herbal medicinal products are often used for the relief of dyspeptic symptoms. AIMS: : To critically assess the evidence for and against herbal medicinal products for the treatment of non-ulcer dyspepsia. METHODS: Systematic searches were performed in six electronic databases and the reference lists located were checked for further relevant publications. No language restrictions were imposed. Experts in the field and manufacturers of identified herbal extracts were also contacted. All randomized clinical trials of herbal medicinal products administered as supplements to human subjects were included. RESULTS: Seventeen randomized clinical trials were identified, nine of which involved peppermint and caraway as constituents of combination preparations. Symptoms were reduced by all treatments (60-95% of patients reported improvements in symptoms). The mechanism of any anti-dyspeptic action is difficult to define, as the causes of non-ulcer dyspepsia are unclear. There appear to be few adverse effects associated with these remedies, although, in many cases, comprehensive safety data were not available. CONCLUSIONS: There are several herbal medicinal products with anti-dyspeptic activity and encouraging safety profiles. Further research is warranted to establish their therapeutic value in the treatment of non-ulcer dyspepsia.