PubMed · 13895882
The source did not provide an abstract. Follow the original record for more information.
Explore connections, maps & timelines
F FULTON, J O ALMEIDA. 1962. Linear relationships in complement fixation.. https://doi.org/10.1017/s0022172400039346
Cite the original work for its findings. Save a collection to share your selection of sources.
KEEP EXPLORING
HIV infection occurs primarily through mucosal surfaces, indicating that protection at mucosal sites may be crucial in prevention and treatment. The host innate and adaptive immune elements provide a level of protection, which differs between mucosal compartments, and appears to be most successful in the oral environment, where transmission is rare. In addition to the distinct oral mucosal architecture and cellular constituents, oral fluids, unlike other mucosal secretions, are rarely a vehicle for HIV infection. Multiple soluble factors may contribute to this antiviral activity, including neutralizing antibodies, secretory leukocyte protease inhibitor (SLPI), antiviral peptides such as defensins and cystatins, glycoproteins including thrombospondin and lactoferrin, and complement components. Understanding the antiviral activities of these and other potential resistance factors is becoming increasingly important in attempts to design treatments in the era of HAART resistance. In this regard, the mechanism of anti-HIV action of SLPI has recently been further elucidated by the discovery of its binding protein/receptor, which plays a key role in the infection of macrophages and may consequently be a novel therapeutic target. Continued elucidation of the unique features of mucosal HIV immunology is essential for understanding HIV pathogenesis and for developing effective vaccines and therapeutics.
Complement activity was first described in the 1890s and the characterisation of this highly complex system has continued ever since. This review traces the history of complement research from its beginnings until it was transformed by the advent of molecular biology in the 1980s. It takes as a focus point the CIBA symposium on Complement held in London in May 1964 and reflects-and is slanted by-the views and research experience of the author.
Explore the source record for details and available documents.