PubMed · 13720206
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J R DAVIS, B SHACKEL. 1960. Changes in the electro-oculogram potential level.. https://doi.org/10.1136/bjo.44.10.606
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Onset of visual motion evokes a component in the EEG, the motion onset VEP. Exploring its motion specificity with a direction-specific adaptation paradigm, previous work demonstrated that less than 50% of the motion onset VEP represents actual motion detection. Here, we tested whether preadaptation of flicker-sensitive mechanisms can help to isolate motion-specific responses in the VEP. Flicker preadaptation was accomplished by limiting dot lifetime in the random-dot kinematograms that we used to study the direction specificity of motion adaptation. With unlimited dot lifetime, motion adaptation reduced the VEP amplitude to 35% (adapted direction) and 50% (opposite direction). With the shortest dot lifetime (40 ms), motion adaptation reduced the amplitude to 55% (adapted direction) and 70% (opposite direction). These findings suggest that random-dot kinematograms with short dot lifetimes could improve the investigation of human motion processing, be it in electrophysiology or other fields. While such stimuli successfully preadapt flicker-related components, they still evoke a sizable response, of which an estimated 70% is motion-specific.
PURPOSE: To describe the clinical manifestations in a patient with Sjögren reticular dystrophy of the retinal pigment epithelium, and the evolution of the disease over a 20-year follow-up period. CASE REPORT: A 45-year-old woman with Sjögren reticular dystrophy of the retinal pigment epithelium was seen for the first time in 1983; the patient underwent 20 years of annual check-ups. RESULTS: Over the follow-up period, fundus photographs, computerized perimetry, electroretinogram, and electro-oculogram findings had either normal or slightly subnormal outcome. CONCLUSIONS: The results confirm that this disease involves only the retinal pigment epithelium and should not be considered a central tapeto-retinal degeneration or late onset retinopathy.
Besides hereditary macular dystrophies as well as acquired and age-related macular degenerations, systemic disorders should also be considered as a rare cause of maculopathy. In particular, myotonic dystrophy (Curschmann-Steinert syndrome), also characterized by the presence of ptosis and a pathognomic star-shaped cataract, should be taken into account since a reticular dystrophy of the retinal pigment epithelium could be observed, resulting in a visual impairment of various degrees. A clinical case have been retrospectively reviewed and reported in this paper.