PubMed · 13573447
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A ISAACS. 1958. [Viral interference].. https://pubmed.ncbi.nlm.nih.gov/13573447/
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Criteria for classifying influenza viruses into genera, types and subtypes have been discussed, with reference to the 6th report of ICTC. The viruses are divided into 2 genera based on the number of the genome RNA segments. Those which contain 8 segments are further divided into types A or B, according to the antigenicity of the NP and M1 proteins. Viruses belonging to type A are finally classified into subtypes according to the serotype of the HA and NA proteins. Thirteen and nine serotypes of HA and NA, respectively, have been identified in nature, where a variety of combination is possible by genetic reassortment. Method for nomenclature of influenza viruses has also been discussed.
The influenza virus RNA replication and transcription have been extensively studied both in infected cell and in vitro systems. The review presents the analysis of experimental data on the molecular mechanisms for influenza virus RNA replication and transcription as well as on the regulation of the synthesis of three kinds of virus-specific RNAs (vRNA, cRNA and mRNA) and their interrelationships. A hypothetical pattern of regulation is presented, providing an explanation for change in the rate of synthesis of RNA segments and their transcripts in the course of the replication cycle.
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