PubMed · 13505644
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R BATAILLE. 1957-11-27. [Recurrent parotitis].. https://pubmed.ncbi.nlm.nih.gov/13505644/
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A new series of voltage-gated sodium channel blockers with potential for treatment of chronic pain is reported. Systematic structure-activity relationship studies, starting with compound 1, led to identification of potent analogs that displayed use-dependent block of sodium channels, were efficacious in pain models in vivo, and most importantly, were devoid of activity against the cardiac potassium channel hERG.
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