PubMed · 13415930
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1957-04-27. FLUOXYMESTERONE.. https://pubmed.ncbi.nlm.nih.gov/13415930/
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The use of androgen therapy to improve the poor quality of semen was assessed on 69 subfertile men. The men were treated with 2 or 4 mg of fluoxymesterone daily up to 12 months. During the course of treatment, the semen samples were analyzed every 3 months and the overall mean values for various semen characteristics were compared before and after the onset of treatment. The sperm motility and normal sperm morphology showed a significant improvement with treatment. Based on overall evaluation, androgen therapy may benefit some patients, while in others it may not significantly alter the semen quality.
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Beneficial effects of zinc therapy in some infertile patients with low seminal zinc concentrations and decreased sperm motility have been reported recently. The effects of zinc therapy, low-dose (5-10 mg/day) androgen therapy, and combination therapy of both zinc and low-dose androgen, on sperm motility and seminal zinc concentration were studied in patients referred to the andrology clinic. Low-dose androgen therapy increased seminal zinc concentrations and sperm motility, only when pretreatment seminal zinc concentrations were low. Furthermore, patients with low seminal zinc concentrations and poor sperm motility showed greater improvement of sperm motility and seminal zinc levels in response to zinc sulfate with fluoxymesterone than did fluoxymesterone alone or zinc sulfate alone, possible due to a synergistic effect of zinc and androgen.