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PubMed · 1337785

Sequence-specific DNA recognition by basic peptides.

T Morii·M Shimomura·I Saito·H Ide·A Murakami·K Makino
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Abstract

A chiral template with C2 symmetry has been used for modeling a dimeric interface of DNA binding protein. An oligopeptide derived from the basic region of MyoD, a recently described "helix-loop-helix" class of DNA binding protein, has been tethered to the template. Among the four models which differ in chirality and polarity with respect to the arrangement of two subunits, only one dimer model with right-handed and C-terminus to C-terminus arrangement of the peptide subunits binds DNA containing native MyoD binding sequence.

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DNADNA-Binding ProteinsFungal ProteinsMuscle ProteinsMyoD ProteinOligopeptidesProtein KinasesSaccharomyces cerevisiae ProteinsStereoisomerismJournal Article

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T Morii, M Shimomura, I Saito, H Ide, A Murakami, K Makino. 1992. Sequence-specific DNA recognition by basic peptides.. https://pubmed.ncbi.nlm.nih.gov/1337785/

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