PubMed · 13131711
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P B GRAWITZ. 1953. [Experimental decrease of conjunctivitis].. https://pubmed.ncbi.nlm.nih.gov/13131711/
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Ocular allergy includes several clinical subtypes ranging from the mild seasonal allergic conjunctivitis to the potentially sight-threatening atopic keratoconjunctivitis. Current therapies, particularly for the severe forms of disease, need to be more localized and with fewer side effects. For this to be achieved, it requires a better understanding of the basic mechanisms involved. In this chapter, recent findings are discussed that suggest that it is important to take an integrated approach, including both immune and structural elements of the eye. This provides potential new strategies for therapy, addressing the influence of structural cells in disease. These might influence the immune processes that take place and, as the structural cells are precisely localized, topical application is likely to be effective.
PURPOSE: To elevate the intraocular pressure (IOP) in eyes with persistent hypotony caused by excess filtration after trabeculectomy. DESIGN: Interventional case series. METHODS: The scleral flap was sutured directly through the conjunctival flap using a round, tapered needle with a 10-0 nylon suture. This procedure has been performed in 10 eyes. RESULTS: The IOP elevated from 2.6 (+/- 1.0) mm Hg to 8.8 (+/- 3.7) mm Hg in 1 week and has been maintained between 6 to 14 mm Hg during the follow-up. Hypotony maculopathy has disappeared in nine eyes. The suture was buried in the conjunctiva spontaneously in 1 week in all cases. No complications developed. CONCLUSIONS: Suturing the scleral flap directly through the conjunctival flap is a simple and effective modality to treat the hypotony caused by excess filtration after trabeculectomy.