PubMed · 13050621
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I P FROHMAN. 1953. Demerol.. https://pubmed.ncbi.nlm.nih.gov/13050621/
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As a basis for a series of studies on the pharmacological, therapeutic, and addictive properties of synthetic drugs with morphine-like effect, this paper deals with chemical aspects of the compounds of this type so far known. Four major groups, each with a fundamentally different chemical structure, are described: pethidine, methadone, morphinan, and dithienylbutenylamine. For each substance belonging to these groups, the formula, synonyms, and methods of synthesis are indicated. A description of pethidine according to the specifications of the Pharmacopoea Internationalis is annexed to the paper.
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