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PubMed · 1281610

T-kininogen, processing and functions.

L M Greenbaum·E Howard·U Albus·C Lapp·X X Gao
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Abstract

Studies are presented which indicate that T-kininogen, the acute phase kininogen of the rat, could be a healing protein because of its properties as a cysteine protease inhibitor. Evidence is also presented that mRNA of T-kininogen synthesis may be a function of interleukin 6 production. A regulatory mechanism is postulated by which SH cofactors could determine if T-kinin is released or whether the T-kininogen molecule would remain intact. Evidence is also presented that T-kinin acts through kinin B2 receptors. No specific binding of bradykinin or T-kinin could be detected in rat heart preparations.

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Acute-Phase ProteinsAmino Acid SequenceAnimalsDexamethasoneGene ExpressionInterleukin-6Kallikrein-Kinin SystemKininogensKininsMolecular Sequence DataProtein Processing, Post-TranslationalRNA, MessengerRatsTranscription, GeneticJournal Article

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L M Greenbaum, E Howard, U Albus, C Lapp, X X Gao. 1992. T-kininogen, processing and functions.. https://doi.org/10.1007/978-3-0348-7321-5_38

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