PubMed · 12797077
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L D Platt. 1991-03-01. Leveling out.. https://doi.org/10.1046/j.1469-0705.1991.01020083.x
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Precision oncology relies on integrating tumour fraction, variant allele frequency, clonal haematopoiesis of indeterminate potential assessment, pathogenicity, and clinical context into next-generation sequencing interpretation, enabling biologically informed and clinically meaningful treatment decisions while reducing the risk of overinterpreting nontumour or nonactionable genomic alterations.