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PubMed · 12743077

SARS update.

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James Maskalyk, John Hoey. 2003-05-13. SARS update.. https://pubmed.ncbi.nlm.nih.gov/12743077/

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Chronic enterocyte infection with coronavirus. One possible cause of the syndrome of tropical sprue?

A man with a gastrojejunostomy and intestinal malabsorption was found to be excreting large numbers of coronavirus-like particles in his stools over a period of at least eight months. Coronavirus-like particles were found in vesicles in degenerating jejunal enterocytes in all of five jejunal biopsies. In a review of electron micrographs, similar structures were found in biopsies from three of 12 patients with classical chronic tropical sprue and in one patient with a sprue-like syndrome associated with agammaglobulinaemia. The hypothesis is advanced that infection with this virus may produce enterocyte damage and may be one cause of the syndrome of tropical sprue.

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