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PubMed · 12638472

[Antiaggregation: aspirin].

A Eichenberger·L Pontiggia·J H Beer
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Abstract

Many randomized trials have shown aspirin as an effective antiplatelet drug for the secondary prevention of cardiovascular events. The NNT (number needed to treat) to prevent 1 vascular event is about 25. The NNH (number needed to harm) inducing one cerebral bleeding is about 1'000, to provoke one severe extracerebral bleeding about 100-200. The primary prevention can be recommended only for high risk patients for cardiovascular events (annual risk of 1-1.5% or more), calculated on the basis of the Framingham data, the Sheffield tables or in analysis of U.S. Preventive Services Task Force. The mechanisms of action, interactions and the "aspirin-resistance" are briefly discussed.

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Administration, OralAdultAge FactorsAgedAnticoagulantsAspirinCardiovascular DiseasesDiabetes ComplicationsDiabetes MellitusDrug InteractionsDrug Therapy, CombinationFemaleFibrinolytic AgentsHemorrhageHumansMalePlatelet Aggregation InhibitorsPrimary PreventionRandomized Controlled Trials as TopicRisk FactorsTime FactorsComparative StudyEnglish AbstractJournal ArticleReview

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A Eichenberger, L Pontiggia, J H Beer. 2003. [Antiaggregation: aspirin].. https://doi.org/10.1024/0040-5930.60.1.15

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