PubMed · 12614098
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Alexander C McLeod. 2003-03-04. Finding ping.. https://doi.org/10.7326/0003-4819-138-5-200303040-00015
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BACKGROUND: Acute coronary syndrome is a major cause of death, morbidity and access in emergency departments (ED). METHODS: We evaluated a point-of-care testing (POCT) for the determinations of cardiac markers in an emergency department (ED), defining the clinical efficiency (management of patient with chest pain) and economic effectiveness (rationalization of preanalytical phase) related to data of Core Lab. RESULTS: The results of analytical performances showed a good correlation (cTnI r(2)=0.89, myoglobin r(2)=0.84, CK-MB r(2)=0.9) between POCT and Core Lab and a significant decrease of the turn around time (TAT): difference of medians=-54 min, 95% CI from -48 to -60 min. CONCLUSIONS: Our data confirmed that the accurate utilization of POCT in the ED assumes an effective triage of patient with chest pain and the improvement of preanalytical phase out of the laboratory (delivery of specimens) and within the laboratory reception, centrifugation. However, efficiency must be linked to methodological and quality control of the Core Lab, mainly through connectivity.
BACKGROUND: The consequences of emergency intubation in Guillain-Barré syndrome are not known. OBJECTIVE: To review data from patients admitted to the intensive care unit with recent diagnosis of Guillain-Barré syndrome and intubation for respiratory failure. DESIGN, SETTING, AND PATIENTS: The database of patients with Guillain-Barré syndrome admitted to the intensive care units during the past 2 decades was reviewed. Emergency intubation was defined as need for ventilation in a patient with sudden dyspnea, cyanosis, or respiratory arrest. Outcome and pulmonary morbidity were assessed by comparing these patients with patients intubated electively. RESULTS: Six patients were intubated for acute respiratory distress and 1 patient for respiratory arrest. Thirty-six patients were intubated electively. Prolonged weaning was twice as common in the emergent group as in the elective group; a larger sample size might have demonstrated statistical significance. One patient with respiratory arrest developed marked anoxic encephalopathy; in all others, no differences were found in mortality, pulmonary morbidity, or duration of ventilatory assistance. None of the emergency intubations occurred in the last 15 years of the study. CONCLUSIONS: Emergency intubation in Guillain-Barré syndrome is uncommon but, when associated with respiratory arrest, can lead to anoxic encephalopathy. Duration of ventilator use and pulmonary morbidity are not increased in these patients.
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